My watch list
my.chemeurope.com  

my.chemeurope.com

With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.

  • My watch list
  • My saved searches
  • My saved topics
  • My newsletter
Register free of charge
Login  
eng  
DeutschEnglishFrançaisEspañol

Diacerein



Diacerein
Systematic (IUPAC) name
4,5-diacetyloxy-9,10-dioxo-anthracene-2-
carboxylic acid
Identifiers
CAS number 13739-02-1
ATC code M01AX21
PubChem 26248
Chemical data
Formula C19H12O8 
Mol. mass 368.294 g/mol
Synonyms Diacetylrhein, diacerhein
Pharmacokinetic data
Bioavailability  ?
Protein binding 99%
Metabolism Hepatic: deacetylation to rhein, later glucuronidation and sulfate conjugation
Half life 4 to 5 hours
Excretion Renal (30%)
Therapeutic considerations
Pregnancy cat.

Lacking information

Legal status
Routes Oral

Diacerein (INN), also known as diacetylrhein, is a drug used in the treatment of osteoarthritis. It works by inhibiting interleukin-1.

A 2005 Cochrane review found diacerein to be slightly, but significantly, more effective than placebo in controlling the pain of osteoarthritis.[1]

Side effects

The most common side effects of diacerein treatment are gastrointestinal, such as diarrhea.[1][2]

References

  1. ^ a b Fidelix TS, Soares BG, Trevisani VF (2006). "Diacerein for osteoarthritis". Cochrane database of systematic reviews (Online) (1): CD005117. doi:10.1002/14651858.CD005117.pub2. PMID 16437519. Free summary
  2. ^ (French) Diacereine. BIAM (March 24, 1999). Retrieved on 2007-06-13.


v • d • e
Anti-inflammatory and antirheumatic products (M01)
Anti-inflammatory and
antirheumatic products, non-steroids		Butylpyrazolidines (Phenylbutazone, Mofebutazone, Oxyphenbutazone, Clofezone, Kebuzone)

Acetic acid derivatives and related substances (Indometacin, Sulindac, Tolmetin, Zomepirac, Diclofenac, Alclofenac, Bumadizone, Etodolac, Lonazolac, Fentiazac, Acemetacin, Difenpiramide, Oxametacin, Proglumetacin, Ketorolac, Aceclofenac, Bufexamac)

Oxicams (Piroxicam, Tenoxicam, Droxicam, Lornoxicam, Meloxicam)

Propionic acid derivatives (Ibuprofen, Naproxen, Ketoprofen, Fenoprofen, Fenbufen, Benoxaprofen, Suprofen, Pirprofen, Flurbiprofen, Indoprofen, Tiaprofenic acid, Oxaprozin, Ibuproxam, Dexibuprofen, Flunoxaprofen, Alminoprofen, Dexketoprofen)

Fenamates (Mefenamic acid, Tolfenamic acid, Flufenamic acid, Meclofenamic acid)

Coxibs (Celecoxib, Rofecoxib, Valdecoxib, Parecoxib, Etoricoxib, Lumiracoxib)

other anti-inflammatory and antirheumatic agents, non-steroids (Nabumetone, Niflumic acid, Azapropazone, Glucosamine, Benzydamine, Glucosaminoglycan polysulfate, Proquazone, Orgotein, Nimesulide, Feprazone, Diacerein, Morniflumate, Tenidap, Oxaceprol, Chondroitin sulfate)
Specific antirheumatic agentsQuinolines (Oxycinchophen) - Gold preparations (Sodium aurothiomalate, Sodium aurothiosulfate, Auranofin, Aurothioglucose, Aurotioprol) - Penicillamine/Bucillamine
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Diacerein". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE