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Dexrazoxane



Dexrazoxane
Systematic (IUPAC) name
4-[1-(3,5-dioxopiperazin-1-yl) propan-2-yl]piperazine-2,6-dione
Identifiers
CAS number 24584-09-6
ATC code V03AF02
PubChem 71384
DrugBank APRD00090
Chemical data
Formula C11H16N4O4 
Mol. mass 268.269 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Dexrazoxane hydrochloride (Zinecard®, Pharmacia) is a medication used to protect the heart against the cardiotoxic side effects of anthracycline chemotherapy. As a derivative of EDTA, dexrazoxane chelates iron, but the precise mechanism by which it protects the heart is not known.

It is also used in oncology as an intravenously delivered antidote following extravasation--an adverse event in which chemotherapies containing anthracylines leak out of the blood vessel and necrotize the surrounding tissue.


v • d • e
Detoxifying agents for antineoplastic treatment (V03AF)
Mesna - Dexrazoxane - Calcium folinate - Calcium levofolinate - Amifostine - Sodium folinate - Rasburicase - Palifermin
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Dexrazoxane". A list of authors is available in Wikipedia.
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