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Dexoxadrol


Dexoxadrol
Systematic (IUPAC) name
(2S)-2-[(4S)-2,2-di(phenyl)-1,3-dioxolan-4-yl]piperidine
Identifiers
CAS number	6495-46-1
ATC code	?
PubChem	3034023
Chemical data
Formula	C₂₀H₂₃N O₂
Mol. mass	309.40 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Legal
Routes	?

Dexoxadrol (Dioxadrol) is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals. Dexoxadrol, along with another related drug etoxadrol, were developed as analgesics for use in humans, but development was discontinued after patients reported side effects such as nightmares and hallucinations.^[1]^[2]

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References

^ Sax M, Wunsch B. Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity. Current Topics in Medicinal Chemistry. 2006;6(7):723-32.
^ Aepkers M, Wunsch B. Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol. Bioorganic and Medicinal Chemistry. 2005 Dec 15;13(24):6836-49.

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