Daytrana

Daytrana (formerly known as MethyPatch) is a medicinal patch marketed by Shire Pharmaceuticals and developed under contract by Noven Pharmaceuticals. In the literature Daytrana is most commonly refered to as Methylphenidate Transdermal System (MTS).

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Daytrana is FDA approved as a once daily treatment of pediatric patients—ages 6 to 12—with Attention Deficit Hyperactivity Disorder.

Noven's original FDA-submission of MethylPatch indicated that it should be used for 12 hours; when the FDA rejected the submission they requested evidence that a shorter time period was safe and effective; Noven provided such evidence and Daytana was approved for the aforementioned indicated use over a 9 hour period. ^[1]

Oral-based methylphenidate pharmaceuticals are subject to first-pass hepatic metabolism and the levo-isomer is extensively metabolized, consequently contributing nothing to the dextro-isomer's clinical value; whereas MTS is transdermal, thus avoids most first-pass hepatic metabolism and the levo-isomer accounts for a thirteenth of MTS's total clinical value.^[2][3]

Daytrana continues this progression toward greater abuse resistance by providing a non-oral, non-granulated package that can be removed at will.