To use all functions of this page, please activate cookies in your browser.
my.chemeurope.com
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
Cremophor ELCremophor EL® is the registered trademark of BASF Corp. for its version of polyethoxylated castor oil. It is prepared by reacting 35 moles of ethylene oxide with each mole of castor oil. The resulting product is a mixture (CAS number 61791-12-6): the major component is the material in which the hydroxyl groups of the castor oil triglyceride have ethoxylated with ethylene oxide to form polyethylene glycol ethers. Minor components are the polyethyelene glycol esters of ricinoleic acid, polyethyelene glycols and polyethyelene glycol ethers of glycerol.[1] . Cremophor EL is a synthetic, nonionic surfactant. Its utility comes from its ability to stabilize emulsions of nonpolar materials in aqueous systems. Additional recommended knowledgeCremophor EL is an excipient or additive in drugs. Therapeutically, modern drugs are rarely given in a pure chemical state, so most active ingredients are combined with excipients or additives such as Cremophor EL [2] Uses
Cremophor EL is used in Taxol (paclitaxel) and has been called as a dose limiting agent because of its toxicities. (A formulation of paclitaxel that uses nanoparticle albumin instead of Cremophor EL is marketed as an alternative.[3][4]) See alsoReferences
|
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cremophor_EL". A list of authors is available in Wikipedia. |