Cosyntropin

ACTH is available as a synthetic derivative in the form of cosyntropin (synthetic ACTH), tradename Cortrosyn®.

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It contains the first 24 amino acids of ACTH but retains full function.^[1]

In patients with low cortisol levels or symptoms of adrencortical insufficiency, cosyntropin can be used to diagnose Addison's disease. A failure for serum cortisol levels to increase after administration of cosyntropin makes a diagnosis of primary adrenocortical insufficiency more likely. An increase in cortisol upon administration of cosyntropin rules out the condition.

References

1. ^ Cortrosyn information