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Corepressor (genetics)



A corepressor is a protein that decreases gene expression by binding to a transcription factor which contains a DNA binding domain. The corepressor is unable to bind DNA by itself. The corepressor can repress transcriptional initiation by recruiting histone deacetylases which catalyze the removal of acyl groups from lysine residues. This increases the positive charge on histones which strengthens in the interaction between the histones and DNA, making the later less accessible to transcription.[1][2]

References

  1. ^ Lazar MA (2003). "Nuclear receptor corepressors". Nucl Recept Signal 1 (Jun 12): e001. doi:10.1621/nrs.01001. PMID 16604174.
  2. ^ Goodson M, Jonas BA, Privalsky MA (2005). "Corepressors: custom tailoring and alterations while you wait". Nucl Recept Signal 3 (Oct 21): e003. doi:10.1621/nrs.03003. PMID 16604171.

See also

v • d • e
Transcription coregulators
CoactivatorsCARM1 - CRTC1 - CBP - NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 - NCOA6 - NCOA7 - PPARGC1A - PPARGC1B - TGFB1I1
CorepressorsNCOR1 - NRIP1 - NCOR2 (SMRT) - PELP-1 - RCOR1 - Rb - SIN3A- SIN3B - Tripartite motif-containing (TRIM24, TRIM28)
ATP-dependent remodeling factorsChromatin Structure Remodeling (RSC) Complex - SWI/SNF
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Corepressor_(genetics)". A list of authors is available in Wikipedia.
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