Cofact

Cofact is a combination of blood clotting factors II, VII, IX and X. It consists of a protein fraction prepared from fresh-frozen human blood plasma. It is used in patients receiving oral anticoagulation therapy for the treatment and prevention of thrombosis when bleeding occurs (e.g. in the brain) requiring rapid action to accelerate coagulation. It is also used when such a patient must undergo an emergency operation treatment. Other indications include a deficiency of one of the included clotting factors, either congenital or due to liver disease. It is available as a powder and solvent for solution for injection.