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Cloxacillin


Cloxacillin
Systematic (IUPAC) name
(2S,5R,6R)-6-{[3-(2-chlorophenyl)-5-methyl- oxazole-4-carbonyl]amino}-3,3-dimethyl-7-oxo- 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Identifiers
CAS number	61-72-3
ATC code	J01CF02
PubChem	6098
DrugBank	APRD00882
Chemical data
Formula	C₁₉H₁₈Cl N₃O₅S
Mol. mass	435.882 g/mol
Pharmacokinetic data
Bioavailability	37 to 90%
Protein binding	95%
Metabolism	?
Half life	30 minutes to 1 hour
Excretion	Renal and biliary
Therapeutic considerations
Pregnancy cat.	B(US)
Legal status
Routes	Oral, IM

Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. It is sold under a number of trade names, including Cloxapen and Orbenin. Cloxacillin is used against staphylococci that produce beta-lactamase.

Additional recommended knowledge

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This drug has a weaker antibacterial activity than benzylpencillin, and is devoid of serious toxicity except for allergic reactions.

v • d • e Antibacterials for systemic use: beta-lactam antibiotics - penicillins (J01C)
Antibiotics	Amoxicillin • Ampicillin • Azlocillin • Carbenicillin • Cloxacillin • Dicloxacillin • Flucloxacillin • Mezlocillin • Nafcillin • Piperacillin • Pivampicillin • Ticarcillin
Beta-lactamase inhibitors	Sulbactam • Tazobactam • Clavulanic acid
Combinations	Ampicillin/sulbactam (Sultamicillin) • Co-amoxiclav