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Clotiazepam



Clotiazepam
Systematic (IUPAC) name
2-(2-chlorophenyl)-9-ethyl-6-methyl- 8-thia-3,6-diazabicyclo[5.3.0]deca-2,9,11-trien-5-one
Identifiers
CAS number 33671-46-4
ATC code N05BA21
PubChem 2811
DrugBank ?
Chemical data
Formula C16H15ClN2OS 
Mol. mass 318.8 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life  ?
Excretion Renal
Therapeutic considerations
Pregnancy cat.

?

Legal status

Schedule IV(US)

Routes Oral

Clotiazepam (marketed under brand name Trecalmo) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Stage 2 NREM sleep is significantly increased by clotiazepam.[1]

Clotiazepam is not approved for sale in the United States or Canada.

References

  1. ^ Nakazawa Y; Kotorii M, Oshima M, Horikawa S, Tachibana H. (31). "Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives.". Psychopharmacologia. 44 (2): 165-71. PMID 709.
v • d • e
Benzodiazepines (N05BA, N05CD)
1,4-Benzodiazepines
Triazolobenzodiazepines
Imidazobenzodiazepines
Oxazolobenzodiazepines
ThienobenzodiazepinesBrotizolam • Clotiazepam • Etizolam
1,5-BenzodiazepinesArfendazam • Clobazam • Lofendazam • Triflubazam
2,3-BenzodiazepinesGirisopam • GYKI-52895 • Nerisopam • Tofisopam
Benzodiazepine ProdrugsAvizafone • Rilmazafone
OthersBentazepam • Ketazolam • Tifluadom • Zolazepam
v • d • e
Psycholeptics: anxiolytics (N05B)
BenzodiazepineAdinazolam - Alprazolam - Bretazenil - Bromazepam - Camazepam - Chlordiazepoxide - Clobazam - Clorazepate - Clonazepam - Clotiazepam - Cloxazolam - Diazepam - Ethyl loflazepate - Etizolam - Fludiazepam - Halazepam - Imidazenil - Ketazolam - Lorazepam - Medazepam - Nordazepam - Oxazepam - Pinazepam - Prazepam - Tofisopam
NonbenzodiazepineAlpidem - Etifoxine - L-838,417 - Ocinaplon - Pagoclone - Panadiplon - Pipequaline - RWJ-51204 - Y-23684
DiphenylmethaneHydroxyzine - Captodiame
CarbamatesEmylcamate - Carisoprodol - Mebutamate - Meprobamate - Phenprobamate - Tybamate
β-CarbolinesAbecarnil - Gedocarnil - SL-651,498
Dibenzo-bicyclo-octadieneBenzoctamine
Azaspirodecanedione
(serotonin agonist)		Buspirone - Gepirone - Tandospirone
OtherMephenoxalone
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Clotiazepam". A list of authors is available in Wikipedia.
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