Clopamide

Clopamide is a piperidine diuretic.

Additional recommended knowledge

Better weighing performance in 6 easy steps

What is the Sensitivity of my Balance?

Essential Laboratory Skills Guide

Mechanism of Action of Clopamide: Clopamide is categorised as a thiazide like drug and works in similar way as the thiazide diuretics do. It acts at the Proximal Convoluted tubule site of the nephron where it inhibits the sodium-chloride cotransporter. Clopamide selectively binds at the chloride binding site of the sodium chloride cotransporter in the PCT cells on the luminal side and thus intereferes with the reabsorption of NaCl and thus causing an equiosmolar excretion of water along with NaCl.