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Clofibrate


Clofibrate
Systematic (IUPAC) name
ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
Identifiers
CAS number	637-07-0
ATC code	C10AB01
PubChem	2796
DrugBank	APRD00879
Chemical data
Formula	C₁₂H₁₅Cl O₃
Mol. mass	242.698 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	Variable, 92–97% at therapeutic concentrations
Metabolism	Hydrolyzed to clofibric acid; hepatic glucuronidation
Half life	Highly variable; average 18–22 hours. Prolonged in renal failure
Excretion	Renal, 95 to 99%
Therapeutic considerations
Pregnancy cat.	B1(AU) C(US)
Legal status	℞-only(US)
Routes	Oral

Clofibrate is a fibrate. It is used in the treatment of cardiovascular disease.

v • d • e Lipid modifying agents (C10)
Statins	Atorvastatin • Cerivastatin • Fluvastatin • Lovastatin • Mevastatin • Pitavastatin • Pravastatin • Rosuvastatin • Simvastatin
Fibrates	Clofibrate • Bezafibrate • Aluminium clofibrate • Gemfibrozil • Fenofibrate • Simfibrate • Ronifibrate • Ciprofibrate • Etofibrate • Clofibride
Bile acid sequestrants	Colestyramine • Colestipol • Colextran • Colesevelam
Niacin and derivatives	Niceritrol • Niacin • Nicofuranose • Aluminium nicotinate • Nicotinyl alcohol • Acipimox
Other	Dextrothyroxine • Probucol • Tiadenol • Benfluorex • Meglutol • Omega-3-triglycerides • Magnesium pyridoxal 5-phosphate glutamate • Policosanol • Ezetimibe