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Clobutinol


Clobutinol
Systematic (IUPAC) name
1-(4-chlorophenyl)-4-dimethylamino-2,3-dimethyl-butan-2-ol
Identifiers
CAS number	14860-49-2
ATC code	R05DB03
PubChem	26937
Chemical data
Formula	C₁₄H₂₂Cl N O
Mol. mass	255.783 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Clobutinol is a cough suppressant distributed by Boehringer-Ingelheim, Novartis's Hexal (Sandoz), Stada and possibly other companies.

Side effects and withdrawal

It was recently determined to cause cardiac arrhythmia in some patients.

Recent studies have indicated that clobutinol has the potential to prolong the QT interval.^[1]^[2].

Boehringer Ingelheim products containing clobutinol were withdrawn from sale in Germany, and the rest of the world, on August 31, 2007^[3] ^[4]^[5].

^ Bellocq C, Wilders R, Schott JJ, et al (2004). "A common antitussive drug, clobutinol, precipitates the long QT syndrome 2". Mol. Pharmacol. 66 (5): 1093-102. doi:10.1124/mol.104.001065. PMID 15280442.
^ Expert statement on BfArM website: [1]. Retrieved 2007-SEP-01.
^ Yahoo! News: Bundesinstitut ruft Hustenmittel zurück [in German]. Retrieved 2007-AUG-31.
^ tagesschau.de: Bundesinstitut verbietet Hustenmittel Clobutinol [in German]. Retrieved 2007-AUG-31.
^ Company Website:Boehringer Ingelheim voluntarily withdraws its clobutinol containing medications [English]. Retrieved 2007-Sep-01.

v • d • e Cough and cold preparations (R05)
Expectorants	Tyloxapol - Potassium iodide - Guaifenesin - Ipecacuanha - Althea root - Senega - Antimony pentasulfide - Creosote - Guaiacolsulfonate - Levoverbenone
Mucolytics	Acetylcysteine - Bromhexine - Carbocisteine - Eprazinone - Mesna - Ambroxol - Sobrerol - Domiodol - Letosteine - Stepronin - Tiopronin - Dornase alfa - Neltenexine - Erdosteine
Cough suppressants: Opium alkaloids and derivatives	Ethylmorphine - Hydrocodone - Codeine - Normethadone - Noscapine - Pholcodine - Dextromethorphan - Thebacon - Dimemorfan - Acetyldihydrocodeine - Zipeprol
Other cough suppressants	Benzonatate - Benproperine - Clobutinol - Isoaminile - Pentoxyverine - Oxolamine - Oxeladin - Clofedanol - Pipazetate - Bibenzonium bromide - Butamirate - Fedrilate - Dibunate - Droxypropine - Prenoxdiazine - Dropropizine - Cloperastine - Meprotixol - Piperidione - Tipepidine - Morclofone - Nepinalone - Levodropropizine - Dimethoxanate