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Chlortalidone


Chlortalidone
Systematic (IUPAC) name
2-chloro-5-(1-hydroxy-3-oxo-1,2-dihydroisoindol-1-yl)- benzenesulfonamide
Identifiers
CAS number	77-36-1
ATC code	C03BA04
PubChem	2732
DrugBank	APRD00127
Chemical data
Formula	C₁₄H₁₁Cl N₂O₄S
Mol. mass	338.767 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	75%
Metabolism	?
Half life	40 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	C (Au), B (U.S.)
Legal status	POM (UK)
Routes	Oral

Chlortalidone (formerly spelled chlorthalidone in the UK) is a thiazide diuretic, used to treat hypertension.

It is also available in the UK as a combination product with the beta blocker atenolol as Co-tenidone.

v • d • e Antihypertensives (C02) and diuretics (C03)
Sympatholytic agents (including alpha)	centrally acting/antiadrenergics (Clonidine, Guanfacine, Methyldopa, Moxonidine, Rescinnamine, Reserpine, Rilmenidine) • ganglion-blocking/nicotinic antagonist (Mecamylamine, Trimethaphan) • peripherally acting/antiadrenergics (Prazosin, Guanethidine, Indoramin, Doxazosin)
Vasodilators	Diazoxide • Hydralazine • Minoxidil • Nitroprusside • Phentolamine
Other antihypertensives	serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan)
Low ceiling diuretics	Thiazide (Bendroflumethiazide, Chlorothiazide, Hydrochlorothiazide) • Chlortalidone • Indapamide • Quinethazone • Mersalyl • Metolazone • Theobromine • Cicletanine
High ceiling diuretics	Loop diuretic (Bumetanide, Furosemide, Torasemide)
Potassium-sparing diuretics	ESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone)