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Cefoxitin


Cefoxitin
Systematic (IUPAC) name
(6S,7R)-4-(carbamoyloxymethyl)-7-methoxy- 8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia- 1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Identifiers
CAS number	35607-66-0
ATC code	J01DC01
PubChem	37194
Chemical data
Formula	C₁₆H₁₇N₃O₇S₂
Mol. mass	427.454 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	minimal
Half life	41-59 min
Excretion	85% urine
Therapeutic considerations
Pregnancy cat.	B
Legal status
Routes	IV

Cefoxitin is a cephamycin antibiotic often grouped with the second−generation cephalosporins. It is also known as Mefoxin.

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Microbiology

Cefoxitin acts by interfering with cell wall synthesis. Its activity spectrum includes a broad range of gram-negative and gram-positive bacteria including anaerobes. It is inactive in vitro to most strains of Pseudomonas aeruginosa and enterococci and many strains of Enterobacter cloacae. Staphlococci resistant to methicillin/oxacillin should be considered resistant to cefoxitin. ^[1]

References

^ Mefoxin Official FDA information at Drugs.com

v • d • e Antibacterials for systemic use: beta-lactam antibiotics - cephalosporins and related (J01D)
First generation	Cefacetrile, Cefadroxil, Cefalexin, Cefaloglycin, Cefaloridine, Cefalotin, Cefapirin, Cefatrizine, Cefazedone, Cefazolin, Cefradine, Cefroxadine, Ceftezole
Second generation	Cefaclor, Cefamandole, Cefmetazole, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefuroxime
Third generation	Cefdinir, Cefditoren, Cefetamet, Cefixime, Cefmenoxime, Cefodizime, Cefoperazone, Cefotaxime, Cefpiramide, Cefpodoxime, Cefsulodin, Ceftazidime, Ceftibuten, Ceftizoxime, Ceftriaxone, Latamoxef
Fourth generation	Cefepime, Cefpirome, Cefquinome
Other beta-lactam antibacterials	Monobactams (Aztreonam), Carbapenems (Meropenem, Ertapenem, Imipenem, Doripenem)