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Cefazolin


Cefazolin
Systematic (IUPAC) name
3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]- 8-oxo-7-([2-(tetrazol-1-yl)acetyl]amino)- 5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylate
Identifiers
CAS number	25953-19-9
ATC code	J01DB04
PubChem	33255
Chemical data
Formula	C₁₄H₁₃N₈O₄S₃
Mol. mass	454.51 g/mol
Pharmacokinetic data
Bioavailability	NA
Metabolism	?
Half life	1.8 hours (given IV) 2 hours (given IM)
Excretion	Renal, unchanged
Therapeutic considerations
Pregnancy cat.	B1(AU) B(US)
Legal status	℞ Prescription only
Routes	Intravenous, intramuscular

Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic.

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The drug is usually administrated either by intramuscular injection (injection into a large muscle) or intravenous infusion (intravenous fluid into a vein).

Indications

Cefazolin is mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. These organisms are common on normal human skin. Resistance to cefazolin is seen in several species of bacteria.

Side effects

Side effects from cefazolin are not common. Possible side effects include:

diarrhea
stomach pain
upset stomach
vomiting

Cefazolin is marketed under the following brand names: Ancef®, Cefacidal®, Cefamezin®, Cefrina®, Elzogram®, Faxilen®, Gramaxin®, Kefazol®, Kefol®, Kefzol®, Kefzolan®, Kezolin®, Novaporin®, and Zolicef®

v • d • e Antibacterials for systemic use: beta-lactam antibiotics - cephalosporins and related (J01D)
First generation	Cefacetrile, Cefadroxil, Cefalexin, Cefaloglycin, Cefaloridine, Cefalotin, Cefapirin, Cefatrizine, Cefazedone, Cefazolin, Cefradine, Cefroxadine, Ceftezole
Second generation	Cefaclor, Cefamandole, Cefmetazole, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefuroxime
Third generation	Cefdinir, Cefditoren, Cefetamet, Cefixime, Cefmenoxime, Cefodizime, Cefoperazone, Cefotaxime, Cefpiramide, Cefpodoxime, Cefsulodin, Ceftazidime, Ceftibuten, Ceftizoxime, Ceftriaxone, Latamoxef
Fourth generation	Cefepime, Cefpirome, Cefquinome
Other beta-lactam antibacterials	Monobactams (Aztreonam), Carbapenems (Meropenem, Ertapenem, Imipenem, Doripenem)

Category: Cephalosporin antibiotics

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cefazolin". A list of authors is available in Wikipedia.

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