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Cefamandole


Cefamandole
Systematic (IUPAC) name
(6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}- 3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo- 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Identifiers
CAS number	34444-01-4 42540-40-9 (nafate)
ATC code	J01DC03
PubChem	456255
Chemical data
Formula	C₁₈H₁₈N₆O₅S₂
Mol. mass	462.505 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	75%
Metabolism	?
Half life	48 minutes
Excretion	Mostly renal, as unchanged drug
Therapeutic considerations
Pregnancy cat.	B1(AU)
Legal status	POM(UK) Discontinued (US)
Routes	Intramuscular, intravenous

Cefamandole (INN, also known as cephamandole) is a broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally.

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Daily Sensitivity Test

Cefamandole is no longer available in the United States.

v • d • e Antibacterials for systemic use: beta-lactam antibiotics - cephalosporins and related (J01D)
First generation	Cefacetrile, Cefadroxil, Cefalexin, Cefaloglycin, Cefaloridine, Cefalotin, Cefapirin, Cefatrizine, Cefazedone, Cefazolin, Cefradine, Cefroxadine, Ceftezole
Second generation	Cefaclor, Cefamandole, Cefmetazole, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefuroxime
Third generation	Cefdinir, Cefditoren, Cefetamet, Cefixime, Cefmenoxime, Cefodizime, Cefoperazone, Cefotaxime, Cefpiramide, Cefpodoxime, Cefsulodin, Ceftazidime, Ceftibuten, Ceftizoxime, Ceftriaxone, Latamoxef
Fourth generation	Cefepime, Cefpirome, Cefquinome
Other beta-lactam antibacterials	Monobactams (Aztreonam), Carbapenems (Meropenem, Ertapenem, Imipenem, Doripenem)