Cation channels of sperm

cation channel, sperm associated 1
Identifiers
Symbol	CATSPER1
Entrez	117144
HUGO	17116
OMIM	606389
RefSeq	NM_053054
UniProt	Q8NEC5
Other data
Locus	Chr. 11 q12.1

cation channel, sperm associated 2
Identifiers
Symbol	CATSPER2
Entrez	117155
HUGO	18810
OMIM	607249
RefSeq	NM_172097
UniProt	Q96P55
Other data
Locus	Chr. 15 q13-q15

cation channel, sperm associated 3
Identifiers
Symbol	CATSPER3
Entrez	347732
HUGO	20819
OMIM	609120
RefSeq	NM_178019
UniProt	Q86XQ3
Other data
Locus	Chr. 5 q31.2

cation channel, sperm associated 4
Identifiers
Symbol	CATSPER4
Entrez	378807
HUGO	23220
OMIM	609121
RefSeq	XM_371237
UniProt	Q7RTX7
Other data
Locus	Chr. 1 p35.3

Cation channels of sperm: This small family of ion channels, normally referred to as Catsper channels or CatSper, is related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca²⁺ channels that seem to be specific to sperm. These channels are required for proper fertilization. The study of these channels has been slow because they do not traffic to the cell membrane in many heterologous systems.

v • d • e Membrane transport protein: ion channels
Ca²⁺: Calcium channel	Voltage-dependent calcium channel (L-type/Ca_vα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Ca_vα(2.1), Q-type, R-type, T-type, β-subunits (β1, β2, β4), γ-subunits (γ2) • Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel
Na⁺: Sodium channel	Na_vα (1.1, 1.2, 1.4, 1.5, 1.7, 1.9) • Na_vβ (1, 3, 4) • Epithelial sodium channel
K⁺: Potassium channel	Voltage-gated (K_vα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 4.2, 4.3, 7.1, 7.2, 7.3, 7.4, 10.1, 11.1/hERG) • K_vβ (1, 2), Shaker gene, KCNE1) • Calcium-activated (BK channel, SK channel, SK3) • Inward-rectifier K_ir (1.1, 2.1, 2.2, 2.3, 3.1, 3.2, 3.4, 4.1, 4.2, 6.1, 6.2)) • Tandem pore domain K2P (1, 2, 3, 4, 6, 9)
Cl^-: Chloride channel	Cystic fibrosis transmembrane conductance regulator
Porin	Aquaporin (1, 2, 3, 4) • Voltage-dependent anion channel (1)
Cations: TRP	TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2)• TRPV (1, 2, 3, 4, 5, 6)
Other/general	Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α3, β3, H1, H2, H4) • Stretch-activated ion channel