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Captodiame


Captodiame
Systematic (IUPAC) name
2-[(4-butylsulfanylphenyl)-phenyl-methyl] sulfanyl-N,N-dimethylethanamine
Identifiers
CAS number	486-17-9
ATC code	N05BB02
PubChem	10240
Chemical data
Formula	C₂₁H₂₉N S₂
Mol. mass	359.594 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral

Captodiame (INN, also known as captodiamine) is an anxiolytic. It is a derivative of diphenhydramine.^[1]

A 2004 study suggested captodiame may be helpful in preventing benzodiazepine withdrawal syndrome in people discontinuing benzodiazepine treatment.^[1]

References

^ ^a ^b Mercier-Guyon C, Chabannes JP, Saviuc P (2004). "The role of captodiamine in the withdrawal from long-term benzodiazepine treatment". Curr Med Res Opin 20 (9): 1347–55. doi:10.1185/030079904125004457. PMID 15383182. Free full text with registration

v • d • e Psycholeptics: anxiolytics (N05B)
Benzodiazepine	Adinazolam - Alprazolam - Bretazenil - Bromazepam - Camazepam - Chlordiazepoxide - Clobazam - Clorazepate - Clonazepam - Clotiazepam - Cloxazolam - Diazepam - Ethyl loflazepate - Etizolam - Fludiazepam - Halazepam - Imidazenil - Ketazolam - Lorazepam - Medazepam - Nordazepam - Oxazepam - Pinazepam - Prazepam - Tofisopam
Nonbenzodiazepine	Alpidem - Etifoxine - L-838,417 - Ocinaplon - Pagoclone - Panadiplon - Pipequaline - RWJ-51204 - Y-23684
Diphenylmethane	Hydroxyzine - Captodiame
Carbamates	Emylcamate - Carisoprodol - Mebutamate - Meprobamate - Phenprobamate - Tybamate
β-Carbolines	Abecarnil - Gedocarnil - SL-651,498
Dibenzo-bicyclo-octadiene	Benzoctamine
Azaspirodecanedione (serotonin agonist)	Buspirone - Gepirone - Tandospirone
Other	Mephenoxalone