Camps quinoline synthesis

The Camps quinoline synthesis (also known as the Camps cyclization) is a chemical reaction whereby an o-acylaminoacetophenone is transformed into two different hydroxyquinolines (products A and B) using hydroxide ion.^[1][2][3][4]

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The relative proportions of the hydroxyquinolines (A and B) produced are dependent upon the reaction conditions and structure of the starting material. Although the reaction product is commonly depicted as a quinoline (the enol form), it is believed that the keto form predominates in both the solid state and in solution, making the compound a quinolone ^[5].

An example of the Camps reaction is given below ^[5]:

References

See also

• Conrad-Limpach synthesis
• Doebner reaction