Cafestol

Cafestol
Systematic (IUPAC) name
(3bS,5aS,7R,8R,10aS,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro- 7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol
Identifiers
CAS number	469-83-0
ATC code	?
PubChem	?
Chemical data
Formula	C20H28O3
Mol. mass	316.439 g/mol
Physical data
Melt. point	158–162 °C (316–324 °F)
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
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Legal status	Legal everywhere
Routes	Oral

Cafestol is a diterpene molecule present in coffee.

A typical bean of Coffea arabica contains about 0.6% cafestol by weight. Cafestol is present in highest quantity in unfiltered coffee drinks such as French press coffee or Turkish coffee. In filtered coffee drinks such as drip brewed coffee, it is present in only negligible amounts.

Studies have shown that regular consumption of boiled coffee increases serum cholesterol by 8% in men and 10% in women. For those drinking filter coffee, the effect was only significant for women.

Cafestol has also shown anticarcinogenic properties in rats.

According to a 2005 study by the Baylor College of Medicine, cafestol may act as an agonist ligand for the genes FXR and PXR, blocking cholesterol homeostasis.