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CYP2C8

cytochrome P450, family 2, subfamily C, polypeptide 8
Identifiers
Symbol	CYP2C8
Entrez	1558
HUGO	2622
OMIM	601129
RefSeq	NM_000770
UniProt	P10632
Other data
Locus	Chr. 10 q24.1

Cytochrome P450 2C8 (abbreviated CYP2C8), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.

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CYP2C8 Ligands

**Selected inducers, inhibitors and substrates of CYP2C8^[1]**
Substrates	Inhibitors	Inducers
cerivastatin (statin) paclitaxel (chemotherapeutic) repaglinide (antidiabetic) torasemide (loop diuretic) ibuprofen (NSAID)	gemfibrozil (hypolipidemic) thiazolidinediones (antidiabetic) rosiglitazone pioglitazone montelukast (leukotriene receptor antagonist) quercetin (antiinflammatory) trimethoprim (antibiotic)	rifampicin (antibiotic)

v • d • e Cytochromes, oxygenases: cytochrome P450 (EC 1.14)
CYP1	A1, A2, B1
CYP2	A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1
CYP3	A4, A5, A7, A43
CYP4	A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1
CYP5-20	CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1)
CYP21-51	CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1)

rosiglitazone is a CYP2C8 substrate

Category: Cytochrome P450

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CYP2C8". A list of authors is available in Wikipedia.