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CYP27A1



cytochrome P450, family 27, subfamily A, polypeptide 1
Identifiers
Symbol CYP27A1
Alt. Symbols CYP27
Entrez 1593
HUGO 2605
OMIM 606530
RefSeq NM_000784
UniProt Q02318
Other data
Locus Chr. 2 q33-qter

CYP27A1is a gene associated with cerebrotendineous xanthomatosis. It encodes a cytochrome P450 oxidase that is commonly known as sterol 27-hydroxylase, an enzyme involved in the biosynthesis of bile acids. The enzyme participates in the degradation of cholesterol to bile acids in both the classic and acidic pathways. In fact, it is initiating the acidic pathway by yielding oxysterols by introducing a hydroxylgroup to the carbon at 27 position in cholesterol.


v • d • e
Cytochrome P450, oxygenases: steroid hydroxylases (EC 1.14)
Side-chain cleavage - 21-hydroxylase - 18-hydroxylase - 11-beta-hydroxylase

17-alpha-hydroxylase - Aromatase

CYP27A1
v • d • e
Cytochromes, oxygenases: cytochrome P450 (EC 1.14)
CYP1A1, A2, B1
CYP2A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1
CYP3A4, A5, A7, A43
CYP4A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1
CYP5-20CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1)
CYP21-51CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1)
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CYP27A1". A list of authors is available in Wikipedia.
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