CD49c

Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Identifiers
Symbol(s)	ITGA3; CD49C; FLJ34631; FLJ34704; GAP-B3; GAPB3; MSK18; VCA-2; VL3A; VLA3a
External IDs	OMIM: 605025 MGI: 96602 Homologene: 21129
Gene Ontology Molecular Function: • receptor activity • calcium ion binding • protein binding Cellular Component: • integrin complex • membrane • integral to membrane • basolateral plasma membrane • synaptosome Biological Process: • neuron migration • cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • memory
RNA expression pattern
Additional recommended knowledge What is the Sensitivity of my Balance? Correct Test Weight Handling Guide: 12 Practical Tips Recognize and detect the effects of electrostatic charges on your balance More reference expression data
Orthologs
	Human	Mouse
Entrez	3675	16400
Ensembl	ENSG00000005884	ENSMUSG00000001507
Uniprot	P26006	Q5SWB9
Refseq	NM_002204 (mRNA) NP_002195 (protein)	NM_013565 (mRNA) NP_038593 (protein)
Location	Chr 17: 45.49 - 45.52 Mb	Chr 11: 94.86 - 94.89 Mb
Pubmed search	[1]	[2]

Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor), also known as ITGA3 and CD49c, is a human gene. ITGA3 is an integrin alpha subunit. It makes up half of the α3β1 integrin duplex.

ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').^[1]

References

Further reading