| CD1d molecule
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| PDB rendering based on 1zt4.
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| Available structures: 1zt4
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| Identifiers
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| Symbol(s)
| CD1D; CD1A; MGC34622; R3
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| External IDs
| OMIM: 188410 MGI: 107674 Homologene: 1337
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| Gene Ontology
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| Molecular Function:
| • receptor activity
• beta-2-microglobulin binding
• exogenous lipid antigen binding
• protein heterodimerization activity
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| Cellular Component:
| • integral to plasma membrane
• membrane
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| Biological Process:
| • detection of bacterium
• T cell selection
• positive regulation of innate immune response
• antigen processing and presentation, endogenous lipid antigen via MHC class Ib
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| RNA expression pattern
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More reference expression data
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| Orthologs
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| Human
| Mouse
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| Entrez
| 912
| 12479
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| Ensembl
| ENSG00000158473
| ENSMUSG00000028076
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| Uniprot
| P15813
| Q91XK9
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| Refseq
| NM_001766 (mRNA)
NP_001757 (protein)
| NM_007639 (mRNA)
NP_031665 (protein)
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| Location
| Chr 1: 156.42 - 156.42 Mb
| Chr 3: 87.08 - 87.09 Mb
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| Pubmed search
| [1]
| [2]
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CD1d is a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. It is the only member of the group 2 CD1 molecules.
Additional recommended knowledge
CD1d presented lipid antigens activate a special class of T cells, known as Natural Killer T (NKT) cells. When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production.
Nomenclature
- CD1d is also known as R3G1
Further reading
- Melián A, Beckman EM, Porcelli SA, Brenner MB (1996). "Antigen presentation by CD1 and MHC-encoded class I-like molecules.". Curr. Opin. Immunol. 8 (1): 82-8. PMID 8729450.
- Joyce S (2001). "CD1d and natural T cells: how their properties jump-start the immune system.". Cell. Mol. Life Sci. 58 (3): 442-69. PMID 11315191.
- Sköld M, Behar SM (2003). "Role of CD1d-restricted NKT cells in microbial immunity.". Infect. Immun. 71 (10): 5447-55. PMID 14500461.
- Brigl M, Brenner MB (2004). "CD1: antigen presentation and T cell function.". Annu. Rev. Immunol. 22: 817-90. doi:10.1146/annurev.immunol.22.012703.104608. PMID 15032598.
- Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects.". Curr. HIV Res. 4 (1): 57-64. PMID 16454711.
- Brutkiewicz RR (2006). "CD1d ligands: the good, the bad, and the ugly.". J. Immunol. 177 (2): 769-75. PMID 16818729.
- Blumberg RS, Terhorst C, Bleicher P, et al. (1991). "Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells.". J. Immunol. 147 (8): 2518-24. PMID 1717564.
- Balk SP, Bleicher PA, Terhorst C (1989). "Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule.". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 252-6. PMID 2463622.
- Calabi F, Jarvis JM, Martin L, Milstein C (1989). "Two classes of CD1 genes.". Eur. J. Immunol. 19 (2): 285-92. PMID 2467814.
- Yu CY, Milstein C (1990). "A physical map linking the five CD1 human thymocyte differentiation antigen genes.". EMBO J. 8 (12): 3727-32. PMID 2583117.
- Martin LH, Calabi F, Milstein C (1987). "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9154-8. PMID 3097645.
- Balk SP, Burke S, Polischuk JE, et al. (1994). "Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium.". Science 265 (5169): 259-62. PMID 7517575.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
- Kawano T, Cui J, Koezuka Y, et al. (1997). "CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides.". Science 278 (5343): 1626-9. PMID 9374463.
- Katabami S, Matsuura A, Chen HZ, et al. (1998). "Structural organization of rat CD1 typifies evolutionarily conserved CD1D class genes.". Immunogenetics 48 (1): 22-31. PMID 9601940.
- Somnay-Wadgaonkar K, Nusrat A, Kim HS, et al. (1999). "Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form.". Int. Immunol. 11 (3): 383-92. PMID 10221650.
- Campbell NA, Kim HS, Blumberg RS, Mayer L (1999). "The nonclassical class I molecule CD1d associates with the novel CD8 ligand gp180 on intestinal epithelial cells.". J. Biol. Chem. 274 (37): 26259-65. PMID 10473580.
- Han M, Hannick LI, DiBrino M, Robinson MA (2000). "Polymorphism of human CD1 genes.". Tissue Antigens 54 (2): 122-7. PMID 10488738.
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