CD18

Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
PDB rendering based on 1l3y.
Available structures: 1l3y, 1yuk
Identifiers
Symbol(s)	ITGB2; LAD; LFA-1; MAC-1; CD18; LCAMB; MF17; MFI7
External IDs	OMIM: 600065 MGI: 96611 Homologene: 20092
Gene Ontology Molecular Function: • receptor activity • protein binding • protein kinase binding Cellular Component: • integrin complex • membrane • integral to membrane Biological Process: • apoptosis • inflammatory response • cell adhesion • leukocyte adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • cell-cell signaling • multicellular organismal development • regulation of cell shape • antimicrobial humoral response • neutrophil chemotaxis • regulation of peptidyl-tyrosine phosphorylation
RNA expression pattern
Additional recommended knowledge How to ensure accurate weighing results every day? Weighing the right way Daily Sensitivity Test More reference expression data
Orthologs
	Human	Mouse
Entrez	3689	16414
Ensembl	ENSG00000160255	ENSMUSG00000000290
Uniprot	P05107	Q542I8
Refseq	NM_000211 (mRNA) NP_000202 (protein)	NM_008404 (mRNA) NP_032430 (protein)
Location	Chr 21: 45.13 - 45.17 Mb	Chr 10: 76.99 - 77.01 Mb
Pubmed search	[1]	[2]

Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit), also known as CD18 or ITGB2, is a human gene.

CD18 is the beta subunit of three different structures:

• LFA-1 (paired with CD11a)
• Macrophage-1 antigen (paired with CD11b)
• Integrin alphaXbeta2 (paired with CD11c)

The ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.^[1]

References

Further reading

See also

• leukocyte adhesion deficiency
• integrin