coactivator-associated arginine methyltransferase 1
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Identifiers
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Symbol
| CARM1
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Entrez
| 10498
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HUGO
| 23393
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OMIM
| 603934
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RefSeq
| XM_032719
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UniProt
| Q86X55
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Other data
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EC number
| 2.1.1.125
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Locus
| Chr. 19 p13.2
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coactivator associated arginine methyltransferase 1-like
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Identifiers
|
Symbol
| CARM1L
|
Entrez
| 256280
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HUGO
| 23392
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RefSeq
| XM_171224
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UniProt
| Q5SZY8
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Other data
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Locus
| Chr. 9 p24.2
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CARM1 (coactivator-associated arginine methyltransferase 1) is an enzyme (EC 2.1.1.125) encoded by the CARM1 gene found in human beings, as well as many other mammals.[1] CARM1 is a secondary coactivator through its association with p160 family (SRC-1, GRIP1, AIB) of coactivators. It is responsible for moving cells toward the inner cell mass in developing blastocysts.[2] This gene also plays an important role in androgen receptors and may play a role in prostate cancer progression.[3][4]
Additional recommended knowledge
See also
- histone-arginine N-methyltransferase
References
- ^ Chen D, Ma H, Hong H, Koh SS, Huang SM, Schurter BT, Aswad DW, Stallcup MR (1999). "Regulation of transcription by a protein methyltransferase". Science 284 (5423): 2174–7. doi:10.1126/science.284.5423.2174. PMID 10381882.
- ^ Torres-Padilla ME, Parfitt DE, Kouzarides T, Zernicka-Goetz M (2007). "Histone arginine methylation regulates pluripotency in the early mouse embryo". Nature 445 (7124): 214–8. doi:10.1038/nature05458. PMID 17215844.
- ^ Hong H, Kao C, Jeng MH, Eble JN, Koch MO, Gardner TA, Zhang S, Li L, Pan CX, Hu Z, MacLennan GT, Cheng L (2004). "Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status". Cancer 101 (1): 83–9. doi:10.1002/cncr.20327. PMID 15221992.
- ^ Majumder S, Liu Y, Ford OH, Mohler JL, Whang YE (2006). "Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability". Prostate 66 (12): 1292–301. doi:10.1002/pros.20438. PMID 16705743.
Transcription coregulators |
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Coactivators | CARM1 - CRTC1 - CBP - NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 - NCOA6 - NCOA7 - PPARGC1A - PPARGC1B - TGFB1I1 |
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Corepressors | NCOR1 - NRIP1 - NCOR2 (SMRT) - PELP-1 - RCOR1 - Rb - SIN3A- SIN3B - Tripartite motif-containing (TRIM24, TRIM28) |
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ATP-dependent remodeling factors | Chromatin Structure Remodeling (RSC) Complex - SWI/SNF |
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