| V-fos FBJ murine osteosarcoma viral oncogene homolog
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| PDB rendering based on 1a02.
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| Available structures: 1a02, 1fos, 1s9k
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| Identifiers
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| Symbol(s)
| FOS; c-fos
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| External IDs
| OMIM: 164810 MGI: 95574 Homologene: 3844
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| Gene Ontology
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| Molecular Function:
| • transcription factor activity
• specific RNA polymerase II transcription factor activity
• sequence-specific DNA binding
• protein dimerization activity
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| Cellular Component:
| • nucleus
• transcription factor complex
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| Biological Process:
| • DNA methylation
• regulation of transcription from RNA polymerase II promoter
• inflammatory response
• nervous system development
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| RNA expression pattern
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Additional recommended knowledge
More reference expression data
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| Orthologs
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| Human
| Mouse
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| Entrez
| 2353
| 14281
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| Ensembl
| ENSG00000170345
| ENSMUSG00000021250
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| Uniprot
| P01100
| Q3U463
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| Refseq
| NM_005252 (mRNA)
NP_005243 (protein)
| NM_010234 (mRNA)
NP_034364 (protein)
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| Location
| Chr 14: 74.82 - 74.82 Mb
| Chr 12: 86.36 - 86.37 Mb
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| Pubmed search
| [1]
| [2]
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In molecular biology, c-Fos is a cellular proto-oncogene belonging to the immediate early gene family of transcription factors. c-Fos has a leucine-zipper DNA binding domain, and a transactivation domain at the C-terminus. Transcription of c-Fos is upregulated in response to many extracellular signals, e.g. growth factors. Additionally, phosphorylation by MAPK, PKA, PKC or cdc2 alters the activity and stability of c-Fos. Members of the Fos family dimerise with Jun to form the AP-1 transcription factor, which upregulates transcription of a diverse range of genes involved in everything from proliferation and differentiation to defense against invasion and cell damage.
The AP-1 complex has been implemented in transformation and progression of cancer, and both Fos and Jun were first discovered in rat fibroblasts.
The viral homologue of c-Fos, v-Fos, is found in the retrovirus Finkel–Biskis–Jinkins murine osteogenic sarcoma virus.
See also
Further reading
- Murphy LC, Alkhalaf M, Dotzlaw H, et al. (1994). "Regulation of gene expression in T-47D human breast cancer cells by progestins and antiprogestins.". Hum. Reprod. 9 Suppl 1: 174-80. PMID 7962462.
- Pompeiano M, Cirelli C, Arrighi P, Tononi G (1997). "c-Fos expression during wakefulness and sleep.". Neurophysiologie clinique = Clinical neurophysiology 25 (6): 329-41. doi:10.1016/0987-7053(96)84906-9. PMID 8904195.
- Herrera DG, Robertson HA (1997). "Activation of c-fos in the brain.". Prog. Neurobiol. 50 (2-3): 83-107. PMID 8971979.
- Velazquez Torres A, Gariglio Vidal P (2002). "[Possible role of transcription factor AP1 in the tissue-specific regulation of human papillomavirus]". Rev. Invest. Clin. 54 (3): 231-42. PMID 12183893.
References
- Karin Milde-Langosch, 2005. The Fos family of transcription factors and their role in tumourigenesis. European Journal of Cancer 41(16):2449-2461. Abstract + Full Text
| Transcription factors and intracellular receptors |
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| (1) Basic domains |
| (1.1) Basic leucine zipper (bZIP) |
Activating transcription factor (1, 2, 3, 4, 5, 6) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3) • GABPA • MAF (B, F, G, K) • NRL • NRF1 • XBP1 |
| (1.2) Basic helix-loop-helix (bHLH) |
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • NEUROD1 • Twist • USF1 |
| (1.3) bHLH-ZIP |
Myc • MITF • SREBP (1, 2) |
| (1.6) Basic helix-span-helix (bHSH) |
AP-2 |
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(2) Zinc finger
DNA-binding domains |
| (2.1) Nuclear receptor (Cys4) |
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP) |
| (2.2) Other Cys4 |
GATA (1, 2, 3, 4, 5, 6) |
| (2.3) Cys2His2 |
General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH: 1, 2) • GLI-Krüppel family (1, 2, 3, YY1) • KLF (2, 4, 5, 6, 10, 11, 12, 13) • Sp1 • zinc finger (3, 35, 43, 146, 148, 165, 217, 268, 281, 350) • Zbtb7 (7A) • ZBT (16, 17, 33) |
| (2.4) Cys6 |
HIVEP1 |
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(3) Helix-turn-helix
domains |
| (3.1) Homeo domain |
ARX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C6, C8, C9, C13, D1, D3, D4, D9, D10, D11, D12, D13) • NANOG • NKX (2-1, 2-5, 3-1) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) |
| (3.2) Paired box |
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9) |
| (3.3) Fork head / winged helix |
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, L2, M1, N3, O3, O4, P1, P2, P3) |
| (3.4) Heat Shock Factors |
HSF1 |
| (3.5) Tryptophan clusters |
ELF (4, 5) • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB |
| (3.6) TEA domain |
transcriptional enhancer factor 1, 2 |
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(4) β-Scaffold factors with
minor groove contacts |
| (4.1) Rel homology region |
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (5, C1, C2, C3, C4) |
| (4.2) STAT |
STAT (1, 2, 3, 4, 5, 6) |
| (4.3) p53 |
p53 |
| (4.4) MADS box |
Mef2 (A, B, C, D) • SRF |
| (4.7) High mobility group |
HNF (1A, 1B) • LEF1 • SOX (3, 4, 6, 9, 10, 13, 18) • SRY • SSRP1 |
| (4.10) Cold-shock domain |
CSDA |
| (4.11) Runt |
CBF (RUNX1, RUNX2, RUNX3) |
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(0) Other
transcription factors |
| (0.2) HMGI(Y) |
HMGA (1, 2) |
| (0.3) Pocket domain |
Rb • RBL1 • RBL2 |
| (0.6) Miscellaneous |
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • Rho/Sigma • R-SMAD |
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