Butyrophenone

Butyrophenone is a chemical compound (a ketone); some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics.

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Butyrophenones are a class of pharmaceutical drugs derived from butyrophenone.

Examples include:

• Haloperidol, the most widely-used drug in this class
• Droperidol, often used for neuroleptanalgesic anesthesia and sedation in intensive-care treatment
• Benperidol, the most potent commonly-used antipsychotic (~ 200 times more potent as chlorpromazine)
• Triperidol, a highly-potent antipsychotic (100 times more potent than chlorpromazine)
• Melperone, a weakly-potent antipsychotic, in Europe commonly used for treatment of insomnia, confusional states, psychomotor agitation, and delirium, in particular, in geriatric patients
• Lenperone
• Domperidone, an dopamine-antagonist antiemetic, derived further from butyrophenone (not being a butyrophenone itself).

The atypical antipsychotic risperidone, although not a butyrophenone, was developed with the structures of benperidol and lenperone as a basis.