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Butyrophenone

Butyrophenone

IUPAC name	1-cyclohexylbutan-1-one
Identifiers
CAS number
PubChem	10315
SMILES	CCCC(=O)C1=CC=CC=C1
Properties
Molecular formula	C₁₀H₁₂O
Molar mass	148.202
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Butyrophenone is a chemical compound (a ketone); some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics.

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Butyrophenones are a class of pharmaceutical drugs derived from butyrophenone.

Examples include:

Haloperidol, the most widely-used drug in this class
Droperidol, often used for neuroleptanalgesic anesthesia and sedation in intensive-care treatment
Benperidol, the most potent commonly-used antipsychotic (~ 200 times more potent as chlorpromazine)
Triperidol, a highly-potent antipsychotic (100 times more potent than chlorpromazine)
Melperone, a weakly-potent antipsychotic, in Europe commonly used for treatment of insomnia, confusional states, psychomotor agitation, and delirium, in particular, in geriatric patients
Lenperone
Domperidone, an dopamine-antagonist antiemetic, derived further from butyrophenone (not being a butyrophenone itself).

The atypical antipsychotic risperidone, although not a butyrophenone, was developed with the structures of benperidol and lenperone as a basis.

v • d • e Psycholeptics: antipsychotics (N05A)
Phenothiazine typical antipsychotics	Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine
Other typical antipsychotics	Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Droperidol, Haloperidol, Trifluperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine)
Atypical antipsychotics	Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Asenapine, Iloperidone, Zotepine)