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Bumetanide



Bumetanide
Systematic (IUPAC) name
3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid
Identifiers
CAS number 28395-03-1
ATC code C03CA02
PubChem 2471
DrugBank APRD00294
Chemical data
Formula C17H20N2O5S 
Mol. mass 364.417 g/mol
SMILES search in eMolecules, PubChem
Pharmacokinetic data
Bioavailability almost complete
Protein binding 97%
Metabolism hepatic
Half life 60-90 minutes
Excretion renal
Therapeutic considerations
Pregnancy cat.

B3(AU) C(US)

Legal status

Prescription Only (S4)(AU) POM(UK) ℞-only(US)

Routes oral

Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in patients in whom high doses of furosemide are ineffective. It is marketed by Hoffmann-La Roche with the brand name Bumex. The main difference between the two substances is in bioavailability. Furosemide is incompletely absorbed in the intestine (40%), and there is substantial inter- and intraindividual differences in bioavailability (range 10-90%). Bumetanide is completely absorbed (80%), and the absorption is not altered when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect.

Bumetanide is 40 times more potent than furosemide (for patients with normal renal function).


v • d • e
Antihypertensives (C02) and diuretics (C03)
Sympatholytic agents (including alpha)centrally acting/antiadrenergics (Clonidine, Guanfacine, Methyldopa, Moxonidine, Rescinnamine, Reserpine, Rilmenidine) • ganglion-blocking/nicotinic antagonist (Mecamylamine, Trimethaphan) • peripherally acting/antiadrenergics (Prazosin, Guanethidine, Indoramin, Doxazosin)
VasodilatorsDiazoxide • Hydralazine • Minoxidil • Nitroprusside • Phentolamine
Other antihypertensivesserotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan)
Low ceiling diureticsThiazide (Bendroflumethiazide, Chlorothiazide, Hydrochlorothiazide) • Chlortalidone • Indapamide • Quinethazone • Mersalyl • Metolazone • Theobromine • Cicletanine
High ceiling diureticsLoop diuretic (Bumetanide, Furosemide, Torasemide)
Potassium-sparing diureticsESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone)
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Bumetanide". A list of authors is available in Wikipedia.
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