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Brimonidine


Brimonidine
Systematic (IUPAC) name
5-bromo-N- (4,5-dihydro-1H-imidazol-2-yl) quinoxalin-6-amine
Identifiers
CAS number	59803-98-4
ATC code	S01EA05
PubChem	2435
DrugBank	APRD00034
Chemical data
Formula	C₁₁H₁₀Br N₅
Mol. mass	292.135 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	liver primarily
Half life	3 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	B
Legal status	unknown
Routes	Ocular, 1 gtt

Brimonidine (bri-MOE-ni-deen ) is a drug used to treat glaucoma. It acts via decreasing aqueous humor synthesis.

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Brimonidine is an alpha2 receptor agonist.

Alpha 2 agonists, through the activation of the Gi GPCR, inhibit the production of AC. This reduces cAMP and hence Aqueous Humour production by the ciliary body.

Side effects

Conjunctivitis
Conjunctival hyperemia
Ocular pruritus
Ocular burning
Conjunctival follicles
Hypertension
Dry mouth
Visual changes
Somnolence

v • d • e Ophthalmologicals: antiglaucoma preparations and miotics (S01E)
Sympathomimetics	Apraclonidine • Brimonidine • Clonidine • Dipivefrine • Epinephrine
Parasympathomimetics	Aceclidine • Acetylcholine • Carbachol • Demecarium • Echothiophate • Stigmine (Fluostigmine, Neostigmine, Physostigmine) • Paraoxon • Pilocarpine
Carbonic anhydrase inhibitors	Acetazolamide • Brinzolamide • Diclofenamide • Dorzolamide • Methazolamide
Beta blocking agents	Befunolol • Betaxolol • Carteolol • Levobunolol • Metipranolol • Timolol
Prostaglandin analogues	Bimatoprost • Latanoprost • Travoprost • Unoprostone
Other agents	Dapiprazole • Guanethidine