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Chloroalkyl etherChloroalkyl ethers are a class of organic compounds with the general structure R-O-(CH2)n-Cl, characterized as an ether connected to a chloromethyl group via a alkane chain Additional recommended knowledgeChloromethyl methyl ether (CMME) is an ether with the formula CH3OCH2Cl. It is used as an alkylating agent and industrial solvent to manufacture dodecylbenzyl chloride, water repellents, ion-exchange resins, polymers, and as a chloromethylation reagent. It is a known human carcinogen [1]. In organic synthesis the compound is used for the introduction of the methoxymethyl(MOM) protecting group.
Closely related compounds of industrial importance are bis(chloromethyl ether) (BCME) (closely related to chemical weapon sulfur mustard) [2] and benzyl chloromethyl ether.
MOM ethersMethyl chloromethyl ether (often abbreviated MOMCl) is used as a protecting group for alcohols. The product formed is a MOM ether. A base such as N,N-diisopropylethylamine is a requirement. The MOM group can be removed by application of dilute acid. An example is the protection of a phenol group [4]: With a benzyl group the protective group becomes a BOM-ether. See also the closely related methylthiomethyl ethers. References
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Chloroalkyl_ether". A list of authors is available in Wikipedia. |