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Bernthsen acridine synthesisThe Bernthsen acridine synthesis is the chemical reaction of a diarylamine heated with a carboxylic acid (or acid anhydride) and zinc chloride to form a 9-substituted acridine.[1][2] Additional recommended knowledgeUsing zinc chloride, one must heat the reaction to 200-270 °C for 24hrs.[3] The use of polyphosphoric acid will give acridine products at a lower temperature, but also with decreased yields. References
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Bernthsen_acridine_synthesis". A list of authors is available in Wikipedia. |