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Benserazide


Benserazide
Systematic (IUPAC) name
2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl) methyl]propanehydrazide
Identifiers
CAS number	14919-77-8
ATC code	?
PubChem	2327
Chemical data
Formula	C₁₀H₁₅N₃O₅
Mol. mass	293.71 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	Renal and fecal
Therapeutic considerations
Pregnancy cat.	B3(AU)
Legal status	POM(UK) (with levodopa)
Routes	?

Benserazide is an inhibitor of DOPA decarboxylase that does not enter the central nervous system. It is often given in combination with L-DOPA (levodopa) as Co-Beneldopa (BAN) (e.g. Madopar® by Roche in UK) in the treatment of Parkinson's disease to prevent the conversion of L-DOPA to dopamine in the periphery (due to its molecular size it can not penetrate the blood brain barrier) the amount that reaches the central nervous system and reducing the required dose, and also decreasing side effects due to the presence of dopamine in the system (outside of the central nervous system). It has no antiparkinson actions when given alone.