Benfotiamine

Benfotiamine (rINN, also known as benfotiamine or benphothiamine) is an allithiamin, a naturally-occurring lipophilic form of thiamine. The primary use of this antioxidant is as an "anti-age" supplement. However, in Germany doctors have been known to combine benfotiamine with pyridoxine hydrochloride and use it to treat patients with nerve damage and nerve pain such as sciatica.

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Benfotiamine has shown to be an effective intervention for the treatment of diabetic retinopathy, neuropathy, and nephropathy, possibly because Benfotiamine is a transketolase activator that directs advanced glycation and lipoxidation end products (AGE's, ALE's) substrates to the pentose phosphate pathway, thus reducing tissue AGEs.