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Benfotiamine


Benfotiamine
Systematic (IUPAC) name
S-[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl- formylamino]-5-phosphonooxypent-2-en-3-yl] benzenecarbothioate
Identifiers
CAS number	22457-89-2
ATC code	A11DA03
PubChem	3032771
Chemical data
Formula	C₁₉H₂₃N₄O₆P S
Mol. mass	466.449 g/mol
Synonyms	S-benzoylthiamine-O-monophosphate
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Benfotiamine (rINN, also known as benfotiamine or benphothiamine) is an allithiamin, a naturally-occurring lipophilic form of thiamine. The primary use of this antioxidant is as an "anti-age" supplement. However, in Germany doctors have been known to combine benfotiamine with pyridoxine hydrochloride and use it to treat patients with nerve damage and nerve pain such as sciatica.

v • d • e Vitamins (A11)
fat soluble	A (Retinol, Beta-carotene, Tretinoin, Alpha-carotene) - D (Ergocalciferol, Cholecalciferol, Dihydrotachysterol, Calcitriol, Calcidiol) - E (Tocopherol, Tocotrienol) - K (Naphthoquinone, Phylloquinone/K1, Menatetrenone/K2)
water soluble: B vitamins	B₁ (Thiamine, Sulbutiamine, Benfotiamine) - B₂ (Riboflavin) - B₃ (Niacin, Nicotinamide) - B₅ (Pantothenic acid, Dexpanthenol, Pantethine) - B₆ (Pyridoxine, Pyridoxal phosphate) - B₇ (Biotin) - B₉ (Folic acid) - B₁₂ (Cyanocobalamin, Hydroxocobalamin, Methylcobalamin, Cobamamide)
water soluble: other	C (Ascorbic acid) - Choline

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Benfotiamine has shown to be an effective intervention for the treatment of diabetic retinopathy, neuropathy, and nephropathy, possibly because Benfotiamine is a transketolase activator that directs advanced glycation and lipoxidation end products (AGE's, ALE's) substrates to the pentose phosphate pathway, thus reducing tissue AGEs.

Categories: Amines | B vitamins | Pyrimidines