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Entecavir


Entecavir
Systematic (IUPAC) name
2-amino-9-[4-hydroxy-3-(hydroxymethyl)- 2-methylidene-cyclopentyl]-3H-purin-6-one
Identifiers
CAS number	142217-69-4
ATC code	J05AF10
PubChem	153941
DrugBank	APRD00948
Chemical data
Formula	C₁₂H₁₅N₅O₃
Mol. mass	277.279 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	13%
Metabolism	?
Half life	128–149 hours
Excretion	Renal 62–73%
Therapeutic considerations
Licence data	EU US
Pregnancy cat.	C(US)
Legal status	℞-only(US)
Routes	Oral

Entecavir (INN) (pronounced /ɛnˈtɛkəvɪr/) is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS).

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Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). It was approved by the U.S. Food and Drug Administration (FDA) in March 2005.

Category: Antivirals