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Bambuterol


Bambuterol
Systematic (IUPAC) name
{3-(dimethylcarbamoyloxy)-5-[1-hydroxy-2-(tert-butylamino) ethyl]phenyl} N,N-dimethylcarbamate
Identifiers
CAS number	81732-46-9
ATC code	R03CC12
PubChem	54766
Chemical data
Formula	C₁₈H₂₉N₃O₅
Mol. mass	367.44 g/mol
Pharmacokinetic data
Bioavailability	20%
Metabolism	Hepatic, extensive Further metabolized to terbutaline by plasma cholinesterase
Half life	13 hours (bambuterol) 21 hours (terbutaline)
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	Unknown
Legal status	℞ Prescription only
Routes	Oral

Bambuterol (INN, marketed by AstraZeneca under the trade names Bambec and Oxeol) is a long acting beta-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline.

v • d • e Drugs for obstructive airway diseases: asthma/COPD (R03)
Adrenergics, inhalants	Short acting β₂-agonists: Salbutamol/Levosalbutamol • Fenoterol • Terbutaline Long acting β₂-agonists (LABA): Bambuterol • Clenbuterol • Formoterol • Salmeterol other: Epinephrine • Isoproterenol • Orciprenaline
Glucocorticoids	Beclometasone • Budesonide • Ciclesonide • Fluticasone • Mometasone
Anticholinergics	Ipratropium • Tiotropium
Mast cell stabilizers	Cromoglicate • Nedocromil
Xanthines	Aminophylline • Theobromine • Theophylline
Leukotriene antagonists	Montelukast • Pranlukast • Zafirlukast
Combination products	Budesonide/formoterol • Fluticasone/salmeterol • Ipratropium/salbutamol