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Avanafil


Avanafil
Systematic (IUPAC) name
4-[(3-Chloro-4-methoxybenzyl)amino]-2- [2-(hydroxymethyl)-1-pyrrolidinyl]-N- (2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
Identifiers
CAS number	330784-47-9
ATC code	?
PubChem	9869929
Chemical data
Formula	C₂₃H₂₆Cl N₇O₃
Mol. mass	483.951 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral

Avanafil is a PDE5 inhibitor being developed for erectile dysfunction.

v • d • e Urologicals (G04)
Acidifiers	Ammonium chloride, Calcium chloride
Urinary antispasmodics (primarily antimuscarinics)	Darifenacin, Emepronium, Flavoxate, Meladrazine, Oxybutynin, Propiverine, Solifenacin, Terodiline, Tolterodine, Trospium
For erectile dysfunction	Alprostadil, Apomorphine, Moxisylyte, Papaverine, Phentolamine, Yohimbine, PDE5 inhibitors (Avanafil, Sildenafil, Tadalafil, Udenafil, Vardenafil)
Other urologicals	Acetohydroxamic acid, Collagen, Dimethyl sulfoxide, Magnesium hydroxide, Pentosan polysulfate, Phenazopyridine, Phenyl salicylate, Succinimide
For benign prostatic hypertrophy	5α-reductase inhibitors: Dutasteride, Finasteride Alpha blockers: Alfuzosin, Doxazosin, Tamsulosin, Terazosin Herbals: Pygeum africanum, Serenoa repens

v • d • e Selective Phosphodiesterase inhibitors (C01CE, G04BE)
PDE1	Vinpocetine
PDE2	EHNA
PDE3	Amrinone, Bucladesine, Enoximone, Milrinone
PDE4	HT-0712, Ibudilast, Mesembrine, Rolipram
PDE5	Avanafil, Sildenafil, Tadalafil, Udenafil, Vardenafil