Ariadne (psychedelic)

Ariadne (α-Et-DOM), or 4-methyl-2,5-dimethoxy-alpha-ethylphenethylamine, is a lesser-known psychedelic drug. It is an analog of 2C-D and DOM. Ariadne was first synthesized by Alexander Shulgin. In his book PIHKAL (Phenethylamines I Have Known and Loved), Shulgin reported testing Ariadne up to a dose of 32mg, and reported that it produces psychedelia and a bare threshold.^[1] Very little data exists about the pharmacological properties, metabolism, and toxicity of Ariadne in humans apart from Shulgin's limited testing.

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However, in more recent animal studies, α-Et-DOM was shown to produce stimulus generalisation in rats trained to respond to the drug MDMA.^[2] This suggests that while α-Et-DOM may lack hallucinogenic effects, it might potentially produce empathogenic effects similar to those of MDMA if used at higher dose ranges, beyond those trialled by Shulgin (the potency of α-Et-DOM in this study was similar to that of MDMA, 1.5mg/kg, which would equate to a dose of ~100mg in a human).

References

See also

• Phenethylamine
• Psychedelics, dissociatives and deliriants

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