My watch list

Aquaretics

An aquaretic is a class of drug that is used to promote aquaresis. They are not strictly speaking diuretics, but are sometimes classified as such.

Additional recommended knowledge

Correct Test Weight Handling Guide: 12 Practical Tips

How to ensure accurate weighing results every day?

Daily Sensitivity Test

Herbal aquaretics include adonis, agrimony, bearberry, buchu, dandelion, heartsease, hydrangea, lady's mantle, larch, and sassafras. These increase blood flow to the kidneys without increasing sodium and chloride resorption, thus causing an increase in urine whilst retaining electrolytes. However, the increase in intravascular fluid volume that they cause translates into an increase vascular resistance, and higher blood pressure.^[1]

Synthetic aquaretics, a new class of drug, are V2 receptor antagonists, such as OPC-31260. These have been used in clinical trials as a treatment for Syndrome of inappropriate antidiuretic hormone (SIADH).^[2]^[3]

References

^ Lucinda G. Miller and Wallace J. Murray (1998). Herbal Medicinals: A Clinician's Guide. Haworth Press, 147. ISBN 0789004666.
^ Toshikazu Saito, San-e Ishikawa, Keishi Abe, Kyuzi Kamoi, Kenichi Yamada, Kurakazu Shimizu, Takao Saruta and Sho Yoshida (April 1997). "Acute Aquaresis by the Nonpeptide Arginine Vasopressin (AVP) Antagonist OPC-31260 Improves Hyponatremia in Patients with Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)". The Journal of Clinical Endocrinology & Metabolism 82 (4): 1054–1057. The Endocrine Society. PMID 9100572.
^ D. A. Warrell, Timothy M. Cox, and John D. Firth (2003). Oxford Textbook of Medicine. Oxford University Press, 211–212. ISBN 0198569785.