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Antrafenine


Antrafenine
Systematic (IUPAC) name
2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl 2-[(7-(trifluoromethyl)quinolin-4-yl)amino]benzoate
Identifiers
CAS number	55300-30-6
ATC code	?
PubChem	68723
Chemical data
Formula	C₃₀H₂₆F₆N₄O₂
Mol. mass	588.543 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	hepatic
Half life	?
Excretion	renal
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	oral

Antrafenine (Stakane) is a piperazine derivative drug invented in 1979. ^[1] It acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen,^[2] but is not widely used as it has largely been replaced by newer drugs.

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References

^ Manoury PM, Dumas AP, Najer H, Branceni D, Prouteau M, Lefevre-Borg FM. Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. Journal of Medicinal Chemistry. 1979 May;22(5):554-9.
^ Leatham PA, Bird HA, Wright V, Seymour D, Gordon A. A double blind study of antrafenine, naproxen and placebo in osteoarthrosis. European Journal of Rheumatology and Inflammation. 1983;6(2):209-11.

Category: Piperazines