My watch list

Antrafenine


Antrafenine
Systematic (IUPAC) name
2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl 2-[(7-(trifluoromethyl)quinolin-4-yl)amino]benzoate
Identifiers
CAS number	55300-30-6
ATC code	?
PubChem	68723
Chemical data
Formula	C₃₀H₂₆F₆N₄O₂
Mol. mass	588.543 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	hepatic
Half life	?
Excretion	renal
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	oral

Antrafenine (Stakane) is a piperazine derivative drug invented in 1979. ^[1] It acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen,^[2] but is not widely used as it has largely been replaced by newer drugs.

Additional recommended knowledge

Essential Laboratory Skills Guide

What is the Correct Way to Check Repeatability in Balances?

Don't let static charges disrupt your weighing accuracy

References

^ Manoury PM, Dumas AP, Najer H, Branceni D, Prouteau M, Lefevre-Borg FM. Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. Journal of Medicinal Chemistry. 1979 May;22(5):554-9.
^ Leatham PA, Bird HA, Wright V, Seymour D, Gordon A. A double blind study of antrafenine, naproxen and placebo in osteoarthrosis. European Journal of Rheumatology and Inflammation. 1983;6(2):209-11.

Category: Piperazines