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Nicotinic antagonist



A nicotinic antagonist is a type of anticholinergic which inhibits the action at nicotinic acetylcholine receptors. These compounds are mainly used for peripheral muscle paralysis in surgery, but some centrally acting compounds such as mecamylamine and 18-methoxycoronaridine block nicotinic acetylcholine receptors in the brain and can be used for treating drug addiction.

Comparison
Mechanism Antagonist Preferred receptor Clinical use
Ganglionic blocking agents Hexamethonium Ganglion type none[1]
Mecamylamine Ganglion type
Trimethaphan Ganglion type Rarely used for blood pressure decrease during surgery[1]
Nondepolarizing neuromuscular blocking agents Atracurium Muscle type muscle relaxant in anaesthesia[1]
Doxacurium Muscle type
Mivacurium Muscle type
Pancuronium Muscle type muscle relaxant in anaesthesia[1]
Tubocurarine Muscle type Rarely used [1]
Vecuronium Muscle type muscle relaxant in anaesthesia[1]
Depolarizing neuromuscular blocking agents Succinylcholine Muscle type
Centrally acting nicotinic antagonists 18-Methoxycoronaridine α3β4

References

  1. ^ a b c d e f Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4.  Page 149


v • d • e
Antihypertensives (C02) and diuretics (C03)
Sympatholytic agents (including alpha)centrally acting/antiadrenergics (Clonidine, Guanfacine, Methyldopa, Moxonidine, Rescinnamine, Reserpine, Rilmenidine) • ganglion-blocking/nicotinic antagonist (Mecamylamine, Trimethaphan) • peripherally acting/antiadrenergics (Prazosin, Guanethidine, Indoramin, Doxazosin)
VasodilatorsDiazoxide • Hydralazine • Minoxidil • Nitroprusside • Phentolamine
Other antihypertensivesserotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan)
Low ceiling diureticsThiazide (Bendroflumethiazide, Chlorothiazide, Hydrochlorothiazide) • Chlortalidone • Indapamide • Quinethazone • Mersalyl • Metolazone • Theobromine • Cicletanine
High ceiling diureticsLoop diuretic (Bumetanide, Furosemide, Torasemide)
Potassium-sparing diureticsESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone)
v • d • e
Muscle relaxants (M03)
Peripherally acting
(primarily antinicotinic,
neuromuscular-blocking drugs)		curare alkaloids (Alcuronium, Dimethyltubocurarine, Tubocurarine) - choline derivatives (Suxamethonium) - other quaternary ammonium compounds (Atracurium, Cisatracurium, Doxacurium chloride, Fazadinium bromide, Gallamine, Hexafluronium, Mivacurium chloride, Pancuronium, Pipecuronium bromide, Rocuronium bromide, Vecuronium) - other (Botulinum toxin)
Centrally actingcarbamic acid esters (Phenprobamate, Carisoprodol, Methocarbamol, Styramate, Febarbamate), Baclofen, Chlormezanone, Chlorzoxazone, Cyclobenzaprine, Lorazepam, Mephenesin, Orphenadrine, Phenyramidol, Pridinol, Tetrazepam, Thiocolchicoside, Tizanidine, Tolperisone
Directly actingDantrolene
v • d • e
Receptor agonists and antagonists (and reuptake inhibitors)
Dopamine receptorDopamine agonist - Dopamine antagonist - Dopamine reuptake inhibitor
5-HT (serotonin) receptorSerotonin receptor agonist - Serotonin antagonist (5-HT3 antagonist) - Serotonin uptake inhibitor (SSRI)
Adrenergic receptoradrenergic agonist (Adrenergic alpha-agonist, Beta2-adrenergic receptor agonist) - adrenergic antagonist (Alpha blocker, Beta blocker) - Adrenergic uptake inhibitor
Acetylcholine receptorcholinergic (Muscarinic agonist, Nicotinic agonist) - anticholinergic (Muscarinic antagonist, Nicotinic antagonist) - Acetylcholinesterase inhibitor
Histamine receptorHistamine agonist - Histamine antagonist (H1, H2)
GABA receptorGABA agonist - GABA antagonist
NMDA receptorNMDA antagonist
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Nicotinic_antagonist". A list of authors is available in Wikipedia.
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