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Dopamine antagonist

A dopamine antagonist is a drug which blocks dopamine receptors by receptor antagonism. There are five types of dopamine receptors in the human body; they are found in the brain, peripheral nervous system, blood vessels, and the kidney).

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Uses and examples

Used as atypical antipsychotics (coupled with a serotonin antagonist): clozapine, risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole

Used as antiemetics: metoclopramide, droperidol, domperidone

Used as tricyclic antidepressants: amoxapine

v • d • e

Drugs for functional gastrointestinal disorders (A03)

Drugs for functional bowel disorders

antimuscarinics: Mebeverine - Dicycloverine - Propantheline

papaverine and derivatives: Papaverine - Drotaverine - Moxaverine

acting on serotonin receptors: 5-HT₃ antagonists (Alosetron, Cilansetron) - 5HT₄ agonists (Mosapride, Tegaserod)

other: Diisopromine - Isometheptene - Phloroglucinol - Proglumide - Tridihexethyl

Belladonna and derivatives
(antimuscarinics)

Atropine - Hyoscyamine - Butylscopolamine - Methylscopolamine

Propulsives

primarily dopamine antagonists (Metoclopramide/Bromopride, Domperidone, Alizapride) - serotonin agonists (Cisapride) - Clebopride

v • d • e Receptor agonists and antagonists (and reuptake inhibitors)
Dopamine receptor	Dopamine agonist - Dopamine antagonist - Dopamine reuptake inhibitor
5-HT (serotonin) receptor	Serotonin receptor agonist - Serotonin antagonist (5-HT₃ antagonist) - Serotonin uptake inhibitor (SSRI)
Adrenergic receptor	adrenergic agonist (Adrenergic alpha-agonist, Beta2-adrenergic receptor agonist) - adrenergic antagonist (Alpha blocker, Beta blocker) - Adrenergic uptake inhibitor
Acetylcholine receptor	cholinergic (Muscarinic agonist, Nicotinic agonist) - anticholinergic (Muscarinic antagonist, Nicotinic antagonist) - Acetylcholinesterase inhibitor
Histamine receptor	Histamine agonist - Histamine antagonist (H₁, H₂)
GABA receptor	GABA agonist - GABA antagonist
NMDA receptor	NMDA antagonist