Androstenediol

Androstenediol is a term used to refer to two different steroids with molecular weights of 290.44: "4-androstenediol" (4-androstene-3beta,17beta-diol) and "5-androstenediol" (5-androstene-3beta,17beta-diol). 4-Androstenediol is closer to testosterone structurally, and has androgenic effects. 5-Androstenediol is a direct metabolite of the most abundant steroid produced by the human adrenal cortex, dehydroepiandrosterone (DHEA). 5-Androstenediol is less androgenic than 4-androstenediol, and stimulates the immune system. When administered to rats in vivo, 5-androstenediol has approximately 1/70 the androgenicity of DHEA, 1/185 the androgenicity of androstenedione, and 1/475 the androgenicity of testosterone (Coffey, 1988). Because it induces production of white blood cells and platelets, 5-androstenediol is being developed as a radiation countermeasure by the Armed Forces Radiobiology Research Institute. Until 2007, it was being developed as a radiation countermeasure by Hollis-Eden Pharmaceuticals as Neumune (HE2100).

Additional recommended knowledge

Daily Visual Balance Check

How to quickly check pipettes?

Weighing the right way

Androstenedio is on the list of substances banned by the Major League Baseball drug policy.

See also

• Neumune
• Androstenedione

References

• MeSH Androstenediol
• PubChem 10634
• Coffey, DS (1988) "Androgen action and the sex accessory tissues". In E Knobil, J Neill (eds), The Physiology of Reproduction. Raven Press, New York, pp 1081-1119.
• Singh VK, Shafran RL, Inal CE, Jackson WE 3rd, Whitnall MH (2005). "Effects of whole-body gamma irradiation and 5-androstenediol administration on serum G-CSF". Immunopharmacol Immunotoxicol 27 (4): 521-34. PMID 16435574.
• Brown GA, McKenzie D (2006). "Acute resistance exercise does not change the hormonal response to sublingual androstenediol intake". Eur J Appl Physiol 97 (4): 404-12. PMID 16636857.
• Head CC, Farrow MJ, Sheridan JF, Padgett DA (2006). "Androstenediol reduces the anti-inflammatory effects of restraint stress during wound healing". Brain Behav Immun. PMID 16730942.
• Suzuki T, Shimizu T, Szalay L, Choudhry MA, Rue LW 3rd, Bland KI, Chaudry IH (2006). "Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsis". Cytokine 34 (1-2): 76-84. PMID 16737821.
• Kiang JG, Peckham RM, Duke LE, Shimizu T, Chaudry IH, Tsokos GC (2007). "Androstenediol inhibits the trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathway". J Appl Physiol 102 (3): 933-41. PMID 17110508.
• Xiao M, Inal CE, Parekh VI, Chang CM, Whitnall MH (2007). "5-Androstenediol promotes survival of gamma-irradiated human hematopoietic progenitors through induction of NF-kappa B activation and G-CSF expression". Mol Pharmacol Epub ahead of print. PMID 17473057.