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Amorolfine



Amorolfine
Systematic (IUPAC) name
(2S,6R)-2,6-dimethyl-4-[2-methyl-3-[4-
(2-methylbutan-2-yl)phenyl]propyl]morpholine
Identifiers
CAS number 60719-84-8
ATC code D01AE16
PubChem 54260
Chemical data
Formula C21H35N 
Mol. mass 317.509 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
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Amorolfine (or amorolfin), is an antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.

Marketed as Curanail, Loceryl, Amorolfine is commonly available in the form of a Nail Lacquer, containing 5% Amorolfine as the active ingredient. It is currently available over the counter in the UK, having recently been re-classified from prescription-only status.

Amorolfine exhibits a broad spectrum of action, meaning that it kills a wide variety of different fungi, and when used as directed can actually cure the infection for a majority of sufferers.

v • d • e
Antifungals (D01 and J02)
AntibioticsGriseofulvin • polyene antimycotics (Natamycin, Nystatin)
Topical azolesimidazoles (Bifonazole, Clomidazole, Clotrimazole, Econazole, Fenticonazole, Ketoconazole, Isoconazole, Miconazole, Oxiconazole, Sertaconazole, Sulconazole, Tioconazole) • triazoles (Fluconazole) • benzimidazole (Thiabendazole)
Other topicalsCiclopirox • Ethylparaben • Flucytosine • Salicylic acid • Selenium sulfide • Tolnaftate • Undecylenic acid • allylamines (Amorolfine, Butenafine, Naftifine, Terbinafine)
For systemic useGriseofulvin • allylamine (Terbinafine) • polyene antimycotic (Amphotericin B) • triazoles (Itraconazole, Posaconazole, Voriconazole) • echinocandins (Anidulafungin, Caspofungin, Micafungin)
OtherTea tree oil • citronella oil • lemon grass • orange oil • patchouli • lemon myrtle
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Amorolfine". A list of authors is available in Wikipedia.
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