My watch list

Alpha 2-antiplasmin

'
Identifiers
Symbol	SERPINF2
Alt. Symbols	PLI
Entrez	5345
HUGO	9075
OMIM	262850
RefSeq	NM_000934
UniProt	P08697
Other data
Locus	Chr. 17 pter-p12

Alpha 2-antiplasmin (or α₂-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin, an important enzyme that participates in fibrinolysis and degradation of various other proteins.

Additional recommended knowledge

Essential Laboratory Skills Guide

Weighing the right way

Guide to balance cleaning: 8 simple steps

Role in disease

Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.

v • d • e Proteins: coagulation
Coagulation factors	intrinsic pathway (FXII, FXI, FIX, FVIII) - extrinsic pathway (Tissue factor, FVII) - common pathway (FX, FV, (Pro)thrombin / FII, Fibrin / FI, FXIII) - HMWK - vWF - Kallikrein
Inhibitors	Antithrombin - Protein C - Protein S - Protein Z - ZPI - TFPI
Fibrinolysis	Plasmin - tPA/urokinase - PAI-1/2 - α2-AP - α2-macroglobulin - TAFI

v • d • e Serpins
inhibitory	Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-antiplasmin - Antithrombin - C1-inhibitor - Heparin cofactor II - Protein C inhibitor - Plasminogen activator inhibitor-1 - Plasminogen activator inhibitor-2 - Protein Z-related protease inhibitor
noninhibitory	Maspin - Ovalbumin - Heat shock protein 47 - Thyroxine-binding globulin - Transcortin

v • d • e Globulins: alpha globulins
Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-macroglobulin - Alpha 2-antiplasmin - Antithrombin - Ceruloplasmin - Haptoglobin - Heparin cofactor II - Orosomucoid - Retinol binding protein - Transcortin