Alpha/beta hydrolase fold


A bacterial lipase, one of this family members

Identifiers
Symbol	Abhydrolase_1
Pfam	PF00561
InterPro	IPR000073
SCOP	1ede
OPM family	135
OPM protein	1qge
Available PDB structures: 1q0zA:52-292 1q0rA:52-292 1y7iA:32-106 1xklB:32-106 1y7hA:32-106 1eb8A:31-252 1dwqA:31-252 1e89B:31-252 1e8dA:31-252 1dwoA:31-252 1dwpA:31-252 1eb9B:31-252 1sc9A:31-251 6yasA:31-251 1sckA:31-251 3yasA:31-251 1sciA:31-251 5yasA:31-251 7yasA:31-251 1qj4A:31-251 1yb7A:31-251 4yasA:31-251 1scqA:31-251 2yasA:31-251 1yb6A:31-251 1m33A:40-251 1a88C:50-272 1a8s :48-270 1a8q :48-271 1va4E:48-268 1a7uA:52-274 1a8uA:52-274 1broB:52-274 1brt :52-274 1hl7B:52-276 1hkhA:52-276 1u2eD:71-288 1ukbA:55-268 1uk7A:55-268 1uk9A:55-268 1c4xA:59-280 1j1iA:66-277 1qtrA:64-315 1wm1A:64-315 1azwA:61-308 1r3dA:43-256 1ehyD:56-291 1qo7B:142-201 2eda :75-305 1ede :75-305 1bez :75-305 1bn6A:59-288 1cqwA:59-288 1bn7A:59-288 1mj5A:56-288 1d07A:56-288 1womB:45-263 1wprB:45-263 1xqxA:56-287 1xrmA:56-287 1xrqA:56-287 1mt3A:56-287 1xqwA:56-287 2b61A:92-353 1tahD:81-334 1qgeD:81-261 1cvl :81-334 4lipE:86-340 3lip :86-340 1ex9A:45-290 1i6wB:78-117 1r50A:78-117 1r4zB:78-117 1t4mA:78-117 1t2nA:78-117 1ispA:78-117 1hlgB:111-391 1k8qA:111-392 1s8oA:286-540 1vj5A:286-540 1cr6A:284-539

The alpha/beta hydrolase fold^[1] is common to a number of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of each enzyme is a alpha/beta-sheet (rather than a barrel), containing 8 strands connected by helices^[1]. The enzymes are believed to have diverged from a common ancestor, preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best conserved structural features of the fold.

Additional recommended knowledge

Safe Weighing Range Ensures Accurate Results

What is the Correct Way to Check Repeatability in Balances?

Daily Sensitivity Test

This catalytic domain is found in a very wide range of enzymes.

Subfamilies

3-oxoadipate enol-lactonase IPR012790

Human proteins containing this domain

ABHD10; ABHD11; ABHD12; ABHD12B; ABHD13; ABHD2; ABHD3; ABHD4; ABHD5; ABHD6; ABHD7; ABHD8; ABHD9; BAT5; BPHL; C20orf135; EPHX1; EPHX2; FAM108B1; LIPA; LIPF; LIPJ; LIPK; LIPM; LIPN; MEST; MGLL; PPME1; SERHL; SERHL2; SPG21;

Categories: Protein domains | Peripheral membrane proteins | Hydrolases