Alpha/beta hydrolase fold


A bacterial lipase, one of this family members

Identifiers
Symbol	Abhydrolase_1
Pfam	PF00561
InterPro	IPR000073
SCOP	1ede
OPM family	135
OPM protein	1qge
Available PDB structures: 1q0zA:52-292 1q0rA:52-292 1y7iA:32-106 1xklB:32-106 1y7hA:32-106 1eb8A:31-252 1dwqA:31-252 1e89B:31-252 1e8dA:31-252 1dwoA:31-252 1dwpA:31-252 1eb9B:31-252 1sc9A:31-251 6yasA:31-251 1sckA:31-251 3yasA:31-251 1sciA:31-251 5yasA:31-251 7yasA:31-251 1qj4A:31-251 1yb7A:31-251 4yasA:31-251 1scqA:31-251 2yasA:31-251 1yb6A:31-251 1m33A:40-251 1a88C:50-272 1a8s :48-270 1a8q :48-271 1va4E:48-268 1a7uA:52-274 1a8uA:52-274 1broB:52-274 1brt :52-274 1hl7B:52-276 1hkhA:52-276 1u2eD:71-288 1ukbA:55-268 1uk7A:55-268 1uk9A:55-268 1c4xA:59-280 1j1iA:66-277 1qtrA:64-315 1wm1A:64-315 1azwA:61-308 1r3dA:43-256 1ehyD:56-291 1qo7B:142-201 2eda :75-305 1ede :75-305 1bez :75-305 1bn6A:59-288 1cqwA:59-288 1bn7A:59-288 1mj5A:56-288 1d07A:56-288 1womB:45-263 1wprB:45-263 1xqxA:56-287 1xrmA:56-287 1xrqA:56-287 1mt3A:56-287 1xqwA:56-287 2b61A:92-353 1tahD:81-334 1qgeD:81-261 1cvl :81-334 4lipE:86-340 3lip :86-340 1ex9A:45-290 1i6wB:78-117 1r50A:78-117 1r4zB:78-117 1t4mA:78-117 1t2nA:78-117 1ispA:78-117 1hlgB:111-391 1k8qA:111-392 1s8oA:286-540 1vj5A:286-540 1cr6A:284-539

The alpha/beta hydrolase fold^[1] is common to a number of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of each enzyme is a alpha/beta-sheet (rather than a barrel), containing 8 strands connected by helices^[1]. The enzymes are believed to have diverged from a common ancestor, preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best conserved structural features of the fold.

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This catalytic domain is found in a very wide range of enzymes.

Subfamilies

3-oxoadipate enol-lactonase IPR012790

Human proteins containing this domain

ABHD10; ABHD11; ABHD12; ABHD12B; ABHD13; ABHD2; ABHD3; ABHD4; ABHD5; ABHD6; ABHD7; ABHD8; ABHD9; BAT5; BPHL; C20orf135; EPHX1; EPHX2; FAM108B1; LIPA; LIPF; LIPJ; LIPK; LIPM; LIPN; MEST; MGLL; PPME1; SERHL; SERHL2; SPG21;

Categories: Protein domains | Peripheral membrane proteins | Hydrolases