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Afterhyperpolarization

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Afterhyperpolarization describes the part of an inactivation phase of an action potential where the membrane falls below the normal resting potential. Both medium and slow afterhyperpolarization currents (mI_AHP and sI_AHP, respectively) can be demonstrated in neurones ^[1]. The SK Channel is the major mediator of AHP currents, although other candidate mediators have been suggested.

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References

^ M. Shah, and D. G. Haylett. Ca2+ Channels Involved in the Generation of the Slow Afterhyperpolarization in Cultured Rat Hippocampal Pyramidal Neurons. J Neurophysiol 83: 2554-2561, 2000.

Category: Electrophysiology