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Alclometasone


Alclometasone
Systematic (IUPAC) name
[7-chloro-11-hydroxy- 10,13,16-trimethyl-3-oxo-17- (2-propanoyloxyacetyl)- 7,8,9,11,12, 14,15,16- octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
Identifiers
CAS number	66734-13-2
ATC code	D07AB10 S01BA10
PubChem	636374
DrugBank	APRD00783
Chemical data
Formula	C₂₈H₃₇Cl O₇
Mol. mass	521.042 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	topical

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Description

Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
Alclometasone Dipropionate marketed as medication Aclovate by GlaxoSmithKline.

Pharmacology

Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).

Indications

Alclometasone cream and onintment are indicated for the relief of corticosteroid-responsive dermatoses, including:

atopic dermatitis

eczema

psoriasis

allergic dermatitis

contact dermatitis

actinic dermatitis

kiss-type allergy

skin itch
Alclometasone may be used on sensetive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.

Contraindications

hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms

cutaneous tuberculosis

chicken pox

perioral dermatitis

acne

rosacea

open wounds

trophic ulcers

viral infection of skin

skin manifestations of syphilis

Side effects

Alclometasone Adverse reactions/Side effects (sometimes, less than 1-2% cases) include:

burning

itching

erythema

skin reddening

xerodermia

skin irritation

acne

hypopigmentation

prickly heat

folliculitis

white atrophy

hypertrichosis

reinfection of skin

How supplied

Alclometasone as Aclovate® is supplied in:

Cream; Topical; 0.05%

Ointment; Topical; 0.05%

Category: Glucocorticoids

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Alclometasone". A list of authors is available in Wikipedia.

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