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ATP citrate lyase



ATP citrate lyase
Identifiers
Symbol ACLY
Entrez 47
HUGO 115
OMIM 108728
RefSeq NM_001096
UniProt P53396
Other data
EC number 2.3.3.8
Locus Chr. 17 q21.2

ATP citrate lyase is an enzyme that represents an important step in fatty acid biosynthesis.

Contents

Reaction

In the presence of ATP and Coenzyme A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and orthophosphate:

citrate + ATP + CoA-->oxaloacetate + Acetyl-CoA + ADP + Pi.

This enzyme was formerly listed as EC 4.1.3.8.[1]

Location

The enzyme is cytosolic in plants[2] and animals.

Structure

The enzyme is composed of two subunits in green plants (including Chlorophyceae, Marchantimorpha, Bryopsida, Pinaceae, monocotyledons, and eudicots), species of fungi, Glaucophytes, Chlamydomonas, and prokaryotes.

Animal ACL enzymes are homomeric, presumably an evolutionary fusion of the ACLA and ACLB genes probably occurred early in the evolutionary history of this kingdom.[3]

References

  1. ^ MeSH ATP+Citrate+Lyase
  2. ^ Kaethner TM, ap Rees T. Planta. 1985;163:290;[1]
  3. ^ http://www.plantphysiol.org/cgi/content/full/130/2/740

This article incorporates text from the National Library of Medicine, a public domain work of the United States Government.

v • d • e
Transferases: acyltransferases (EC 2.3)
2.3.1: other than amino-acyl groups
(mostly acetyltransferases)		N-Acetylglutamate synthase - Choline acetyltransferase - Acetyl-Coenzyme A acetyltransferase - Dihydrolipoyl transacetylase - Acetyl-CoA C-acyltransferase - Beta-galactoside transacetylase - Carnitine O-palmitoyltransferase (CPT1, CPT2) - Acyltransferase like 2 - Chloramphenicol acetyltransferase - Aminolevulinic acid synthase - Beta-ketoacyl-ACP synthase - Glyceronephosphate O-acyltransferase - Lecithin-cholesterol acyltransferase - Histone acetyltransferase (P300/CBP) - Serotonin N-acetyl transferase
2.3.2 - AminoacyltransferasesGamma glutamyl transpeptidase - Peptidyl transferase - Transglutaminase (Tissue transglutaminase, Keratinocyte transglutaminase, Factor XIII)
2.3.3 - converted into alkyl on transferCitrate synthase - ATP citrate lyase - HMG-CoA synthase
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "ATP_citrate_lyase". A list of authors is available in Wikipedia.
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